Synthesis, characterization and in vitro anti mycobacterial activity of some novel benzothiazole derivatives

World Health Organization considers Mycobacterium tuberculosis is the most dangerous chronic transmittable disease. Development of resistance by a common problem world Wide. To combat these problems there could be solution that we should search newer molecules with different mechanism action to fight against such diseases. A series some novel benzothiazole derivatives (I-X) have been synthesized and evaluated for their in vitro antimycobacterial activity H37Rv using Microplate Alamar Blue Assay Method (MABA). Structures compounds were supported means IR, NMR MASS spectral studies. Among compounds, compound [IX], 2-[5-(4-Bromophenyl)-2-furylcarboxamido]-6-methoxy-l,3-benzothiazole exhibited significant when compared standard drug Isoniazid. This remarkable starting point develop new lead potential antitubercular activity.